What is the mechanism of action of SGLT2 inhibitors and name potential benefits beyond glycemic control.

• A. They increase glucose reabsorption in the proximal tubules.
• B. They block glucose reabsorption in proximal tubules, causing glucosuria; benefits include weight loss, blood pressure reduction, and reduced risk of heart failure hospitalizations and CKD progression.
• C. They primarily stimulate insulin secretion from pancreatic beta cells.
• D. They increase hepatic glucose production.

Answer: (B)