Which of the following are signs of thyroid hormone overdose?

• A. Hair loss and dry skin
• B. Slow heart rate and fatigue
• C. Weight gain and cold intolerance
• D. Fever, rash, metallic taste, mouth sores, GI distress

Answer: (D)

Overdose of thyroid hormone drives the body toward a hyperactive state and can produce adverse effects beyond the usual metabolic upsurge. Among the given signs, fever, rash, metallic taste, mouth sores, and GI distress fit best as manifestations you might see with excessive thyroid hormone exposure or drug intolerance, reflecting systemic reactions to over-replacement.

The other descriptions point more clearly to hypothyroidism or under-replacement—hair loss and dry skin, slow heart rate with fatigue, and weight gain with cold intolerance—so they don’t align with an overdose picture. In real clinical practice, overdose commonly brings tachycardia, palpitations, heat intolerance, weight loss, and tremor, but within these options, the mucocutaneous and GI/systemic adverse-effect cluster is the closest match to an overdose/toxicity profile.